• Circum-Arctic distribution of chemical anti-herbivore compounds suggests biome-wide trade-off in defence strategies in Arctic shrubs 

      Lindén, Elin; te Beest, Mariska; Aubreu, Ilka; Moritz, Thomas; Sundqvist, Maja K.; Barrio, Isabel C.; Boike, Julia; Bryant, John P.; Bråthen, Kari Anne; Buchwal, Agata; Bueno, C. Guillermo; Currier, Alain; Egelkraut, Dagmar Dorothea; Forbes, Bruce C.; Hallinger, Martin; Heijmans, Monique; Hermanutz, Luise; Hik, David S.; Hofgaard, Annika; Holmgren, Milena; Huebner, Diane C.; Høye, Toke T.; Jónsdóttir, Ingibjörg S.; Kaarlejärvi, Elina; Kissler, Emilie; Kumpula, Timo; Limpens, Juul; Myers-Smith, Isla H.; Normand, Signe; Post, Eric; Rocha, Adrian V.; Schmidt, Niels Martin; Skarin, Anna; Soininen, Eeva M; Sokolov, Aleksandr; Sokolova, Natalia; Speed, James David Mervyn; Street, Lorna E.; Tananaev, Nikita; Tremblay, Jean-Pierre; Urbanowicz, Christine; Watts, David A.; Zimmermann, Heike H.; Olofsson, Johan (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-30)
      Spatial variation in plant chemical defence towards herbivores can help us understand variation in herbivore top–down control of shrubs in the Arctic and possibly also shrub responses to global warming. Less defended, non-resinous shrubs could be more influenced by herbivores than more defended, resinous shrubs. However, sparse field measurements limit our current understanding of how much of the ...
    • Gibberellin mediates daylength-controlled differentiation of vegetative meristems in strawberry (Fragaria × ananassa Duch) 

      Junttila, Olavi; Hytönen, Timo; Elomaa, Paula; Moritz, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-02-11)
      Background: Differentiation of long and short shoots is an important developmental trait in several species of the Rosaceae family. However, the physiological mechanisms controlling this differentiation are largely unknown. We have studied the role of gibberellin (GA) in regulation of shoot differentiation in strawberry (Fragaria × ananassa Duch.) cv. Korona. In strawberry, differentiation of ...
    • Lipidomics in ulcerative colitis reveal alteration in mucosal lipid composition associated with the disease state 

      Diab, Joseph; Hansen, Terkel; Goll, Rasmus; Stenlund, Hans; Ahnlund, Maria; Jensen, Einar; Moritz, Thomas; Florholmen, Jon; Forsdahl, Guro (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-11)
      <p><i>Background - </i>The onset of ulcerative colitis (UC) is associated with alterations in lipid metabolism and a disruption of the balance between pro- and anti-inflammatory molecules. Only a few studies describe the mucosal lipid biosignatures during active UC. Moreover, the dynamics of lipid metabolism in the remission state is poorly defined. Therefore, this study aims to characterize mucosal ...
    • Mucosal Metabolomic Profiling and Pathway Analysis Reveal the Metabolic Signature of Ulcerative Colitis 

      Diab, Joseph; Hansen, Terkel; Goll, Rasmus; Stenlund, Hans; Jensen, Einar; Moritz, Thomas; Florholmen, Jon; Forsdahl, Guro (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-27)
      The onset of ulcerative colitis (UC) is characterized by a dysregulated mucosal immune response triggered by several genetic and environmental factors in the context of host–microbe interaction. This complexity makes UC ideal for metabolomic studies to unravel the disease pathobiology and to improve the patient stratification strategies. This study aims to explore the mucosal metabolomic profile in ...
    • A Quantitative Analysis of Colonic Mucosal Oxylipins and Endocannabinoids in Treatment-Naïve and Deep Remission Ulcerative Colitis Patients and the Potential Link With Cytokine Gene Expression 

      Diab, Joseph; Al-Mahdi, Rania; Gouveia, Sandra; Hansen, Terkel; Jensen, Einar; Goll, Rasmus; Moritz, Thomas; Florholmen, Jon; Forsdahl, Guro (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-22)
      <p><i>Background</i> - The bioactive metabolites of omega 3 and omega 6 polyunsaturated fatty acids (ω-3 and ω-6) are known as oxylipins and endocannabinoids (eCBs). These lipid metabolites are involved in prompting and resolving the inflammatory response that leads to the onset of inflammatory bowel disease (IBD). This study aims to quantify these bioactive lipids in the colonic mucosa and to ...
    • Serum metabolomic biomarkers of dementia 

      Mousavi, Malahat; Jonsson, Pär; Antti, Henrik; Adolfsson, Rolf; Nordin, Annelie; Bergdahl, Jan; Eriksson, Kåre; Moritz, Thomas; Nilsson, Lars-Göran; Nyberg, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)